Behavioural phenotyping of thunder mice with a hypomorphic mutation of heterogeneous nuclear ribonuclear protein L-like (hnRNPLL) and reduced T cell function

• hnRNPLL is abundantly expressed in immune memory T lymphocytes and the brain. hypomorphism thunder mice ( hnrpll ) causes cell deficits. show enhanced tail suspension immobility reduced learning/memory. subtle prepulse intensity-related inhibition. No changes forced swim test, plus-maze, startle or exploratory habituation. Heterogeneous nuclear ribonuclear protein l -like (hnRNPLL) an RNA binding that regulates alternative splicing of mRNA system A hypomorphic allele gene encoding Hnrpll selectively reduces accumulation lymphoid tissues, but little known about its effects Therefore, we exposed to a test battery with relevance for range psychiatric illnesses. Thunder showed tail-suspension depression-related behaviours, impaired short-term spatial Y-maze avoidance learning active test. Thus, addition reported on function, mutation affected aspects behaviour.